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pentobarbital will increase the stage or impact of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of ivosidenib with powerful CYP3A4 inducers reduced ivosidenib plasma concentrations.pentobarbital will reduce the level or result of darifenacin by impacting hepatic/intestina